New PDF release: Anxiety, Depression, and Emotion

By Richard J. Davidson

ISBN-10: 0195133587

ISBN-13: 9780195133585

ISBN-10: 0195350863

ISBN-13: 9780195350869

By way of targeting the connection among simple learn in emotion and emotional disorder in melancholy and nervousness, this exact quantity offers either mental and organic implications of analysis for psychiatrists and psychologists.

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Extra info for Anxiety, Depression, and Emotion

Example text

For approximately 10 years, we have been using selective breeding techniques in an attempt to develop new rat models for depression and/or to substantially improve rodent models already in use. The rationale underlying this approach is that serious mental illness is characterized by genetic susceptibility and, consequently, better animal models are likely to be based on specific strains of animals that either spontaneously display relevant behavioral characteristics or readily express such behavior under appropriate environmental conditions, such as when exposed to stressful circumstances.

Figure 1-3 shows the contrast between what occurs when a single electrical pulse is delivered to the LC and what happens when 20 pulses are delivered to the LC prior to electrophysiological recording from a DA cell in the VTA. Whereas a single pulse causes excitation of the DA cell, multiple pulses delivered to the LC result in profound inhibition of the VTA-DA cell. From the perspective of â stress-induced behavioral depression,â Grenhoff et al. appeared to have discovered a circumstance in which heightened LC activity inhibits DA cell depolarization, thus potentially providing the link between the NE and DA systems that is needed to describe the pathophysiology of stress-induced depression.

To assess effects of antidepressants, animals were tested after receiving drugs or vehicle for 14 days via subcutaneous Alzet minipumps. 0 s in a 15-min test) in comparison to what was seen in animals not exposed to this stressor (mean ± S. E. 1 s). 24 imipramine (10 mg/kg/day), desipramine (10 mg/kg/day), amitriptyline (10 mg/kg/day), bupropion (20 mg/kg/day), phenelzine (5 mg/kg/day), venlafaxine (20 mg/kg/day), fluoxetine (16 mg/kg/day) and sertraline (25 mg/kg/day) (see figure 1-10). Also, electroconvulsive shock (administered twice, 1 week apart, with testing 1 week after last shock) likewise blocked any stress-induced decrease in struggling.

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Anxiety, Depression, and Emotion by Richard J. Davidson


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