By Dr. Hans Wolfgang Kölmel (auth.)
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Extra resources for Atlas of Cerebrospinal Fluid Cells
A benign lymphocytic meningitis may also be observed accompanying mumps and almost all herpes zoster infections. Pleocytosis of the CSF is often very limited in cases of herpes zoster meningitides (40/mm 3), extensive in the majority of Coxsackie infections (up to 3,OOO/mm 3) and does not exceed I,OOO/mm 3 in most forms of viral meningitis. There seems to be no correlation between the number of cells in the spinal fluid and the severity of illness, although it is most often the meningitis accompanied by a limited pleocytosis that is clinically asymptomatic.
Eosinophils can be present in any infectious pleocytosis, but they usually constitute less than I % of the total number of cells. It is well known that one stage of cellular reaction to infection is characterized by the appearance of eosinophils . In our experience, eosinophils are relatively more numerous in so-called lymphocytic meningitis than in bacterial meningitis. They appear most often in the cellularity that accompanies tuberculous meningitis, although not in the entire course of the disease.
The presence of certain vestiges, such as fat vacuoles, hemosiderin, and hematoidin, allows conclusions as to the origin and the phagocytic activity of the cells. In addition to the giant cells, which may be regarded as special forms of macrophages, there are other types which appear in the course of subacute or chronic, specific or unspecific infections of the CNS [93, 122, 174]. These are remarkable for a more pronounced cytoplasmic coloration, to the point of extreme cytoplasmic basophilia. A high rate of mitosis is an additional indication of the activity of these cells.
Atlas of Cerebrospinal Fluid Cells by Dr. Hans Wolfgang Kölmel (auth.)